Pre-Conference Workshop Day

Tuesday, December 10, 2024

Day One

Workshop A

9.00 - 12.00

ADC Target Biology 101: A Mechanistic Deep Dive Into Your ADC Targets

As the ADC field advances, there is a growing emphasis on incorporating a stronger biological focus into ADC target selection. With an increasingly crowded landscape of ADC developers, a “first-in-class” approach to identifying novel targets that align with the intricate mechanisms of ADC design is essential. For this reason, a deep understanding of the biological interactions between ADCs and their targets remains fundamental to successful target selection.

This workshop provides a premium platform to immerse yourself in the biological discussion around ADC target selection, shifting the angle of approach to identifying the next best target.

Gather with experts to:

  • Dissect the role of the ADC target through a biological lens to correlate accordingly
    with ADC design
  • Review target properties which have a pivotal role in functionality, including
    expression, stability, and localization
  • Align the biological and chemical strategy for ADC target selection to create a
    holistic profile
Andrew Zhang - Former AZ - 4th ADC Target Selection

Andrew Zhang
Director, Chemical
Biology
Former AstraZeneca

Lunch & Networking

12:00

Workshop B

1.00 - 4.00

Stop Chasing Shiney Bandwagons: Strategies for Discovery & Development of Innovative ADC Targets

Everyone is seeking novel targets, but where do we start?Laying out an in-depth plan of action when strategizing your ADC target selection efforts is paramount to success. A multifactorial approach is required to inform your novel target choice, seeking multiple perspectives to the decision making process. This workshop will outline the decision- making tree from concept to clinic to create a bulletproof strategy to propel your ADC target selection.

Gather with experts to:

  • Explore how targets for ADC development require special considerations including
    biology, copy numbers, homogeneity, and stability in expression
  • Discuss internalizing versus non-internalizing targets
  • Learn how target discovery requires validation using appropriate linkers, payloads
    and conjugation
  • Outline five rights to target selection, including bispecific tumor targets
  • Identify the do’s and don’ts of target selection
Rakesh Dixit - Bionavigen - ADC Target Selection Summit

Rakesh Dixit
CEO & President
Bioavigen Oncology

End of Pre-Conference Workshop Day

4:00

FULL SPEAKER FACULTY
CONFERENCE DAY ONE