10:00 am Chair’s Opening Remarks
Looking at Novel Targets & the Clinical Development for Solid Tumors
10:00 am Identification of Novel pHLA Targets for Solid Tumor Targeting with ADCs
Synopsis
- Discuss the advantages of intracellular targets (pHLAs) versus viral, neoantigens or conventional cell surface antigens
- Uncover strategies to find the most prevalent and immunogenic pHLA targets in tumors from CPI responders
- Review the selection of ADCs targeting pHLA targets to avoid off-tumor, on-target toxicities in normal tissues
10:30 am Development & Clinical Translation of ELU001, a Targeted Ultra- Small Topoisomerase 1 C’Dot Conjugate for the Treatment of Solid Tumors
Synopsis
- ELU001 is an ultra-small, 6 nM exatecan conjugated C’Dot Drug Conjugate (CDC) that is targeted to Folate Receptor Alpha via folic acid moieties on its surface
- Understanding how Folate Receptor Alpha is an ideal target for CDC therapy due to its over expression on a variety of tumors and its limited expression on healthy tissues
- Due to their size and neutral properties C’Dot Drug Conjugates (CDCs) localize in and penetrate rapidly into solid tumors including difficult to access tumors in the brain and pancreas
11:00 am Virtual Speed Networking
Synopsis
This session is the ideal opportunity to get face-to-face time with many of the brightest minds working in the ADC Targets field and establish meaningful business relationships to pursue for the rest of the conference.
12:00 pm SOT102, A Novel CLDN18.2-Targeting Antibody-Drug Conjugate With Strong Therapeutic Potential in Solid Tumors
Synopsis
- SOT102 is based on a novel proprietary CLDN18.2 specific monoclonal antibody, conjugated to PNU-159682
- Evaluate how SOT102 demonstrated strong antitumor activity in mouse
- PDX models of gastric, pancreatic and other solid tumors, including those with low target expression
- Gain an update on a Phase 1/2 study in patients with gastric and pancreatic cancer that is planned to start in early 2022
12:30 pm Quantitative Proteomics Approaches for ADC Target Characterization
Synopsis
- Discuss DIA-MS peptide level quantification for epitope and isoform precision
- Explore how to quantify cell surface protein dynamics using pulsed SILAC labeling
- Examine the profiling of protein drug interactions (PDIs) using IP-MS
1:00 pm Lunch & Networking
2:00 pm Target Identification at the Intersection of Indication & Payload
Synopsis
- Highlight the multifactorial aspect of target identification
- Discuss the significance of comprehensive understanding of antigen expression as function of stage of tumorigenesis
- Illustrate the enhanced value of pairing payload mechanism and indication