8:30 am Registration & Morning Refreshments

9:15 am Chair’s Opening Remarks

Optimizing Pairing of Target, Antibody & Linker-Payload Technologies

9:30 am Showcasing Affilins® – a Novel, Best-in-Class Targeting Platform

Synopsis

  • Breaking paradigms in tumor accumulation
  • Unprecedented modularity for fast innovation cycles multi-specifics without limits

10:00 am Uncovering Why Topoisomerase-1 Payloads Have Had Great Success in ADC Development

Synopsis

  • Discussing benefits of utilising Topo-1 payloads as ADC warhead
  • Understanding why Topo-1 payloads have been successful in ADC development
  • Linking target selection with payload selection: what has topo-1 allowed us to do in terms of targets?

10:30 am Morning Refreshments

11:30 am Implications of Patient Selection When Utilizing Novel ADC Targets

  • Matthew Eaton Vice President Computational Biology and Bioinformatics, Precede Biosciences

Synopsis

  • Identifying what is relevant in pre-treated patients
  • Discussing biomarkers to identify patients who will respond well to an ADC target
  • Targeting certain oncology patients in a novel method

Advancing Your Understanding of Target Biology to Aid in Target Selection

12:00 pm Roundtable Discussion: Delving Into Fc Function for Target Specificity: Is It Always Necessary?

  • Zhinan Xia Chief Scientific Officer, Dynamicure Biotechnology

Synopsis

  • Determining if Fc function is necessary for your Fc target specificity
  • Exploring better choices when wanting to avoid Fc Function
  • Understanding cytotoxic effects linked to Fc function

12:30 pm Networking Lunch

Overcoming Challenges in Clinical Applicability & Pipeline Development in the ADC Sphere

1:30 pm Pre-Clinical Discovery & Evaluation of BoltbodyTM Immune-Stimulating Antibody Conjugates (ISACs) for Solid Tumors

Synopsis

  • Delving into the story of pre-clinical discovery of ISACs
  • Outlining how ISACs are beneficial in the pursuit of treatments for solid tumours
  • Evaluating the Boltbody ISAC

2:00 pm Closing Networking Session & Refreshments