WORKSHOP A

What Makes a Good Target?
11:00am-1:00pm

This interactive workshop will equip you with the core skills and understanding in critical areas of what makes a good
ADC target. Covering essential elements in ADC target discovery and early development, this workshop will enable you to:

• Understand the impact of conjugation site selection on your ADC
• Choose the optimum “antibody” format
• Select the most appropriate ADC target which is easily accessible
• Learn about cellular assays

Workshop Leader:

John Lambert - ImmunoGen

 

 

 

John Lambert

Independent
Consultant

WORKSHOP B

Target Selection & Methods to Mitigate ON-Target/OFF-Tumor Toxicity
2:00pm-4:00pm

This workshop will review in detail target selection criteria and processes. We will discuss properties that are critical
for maximizing ADC efficacy, resources for the target identification process, and evaluate some successes and
failures of ADC programs from the point of view of target selection.

We will also discuss ways to approach drugging non-ideal targets, particularly due to high normal healthy tissue expression, and methods such as protease-activatable prodrug ADCs that can convert undruggable targets to ones having a viable therapeutic index.

Workshop Leaders:

Rakesh Dixit - MedImmune
Jagath-Reddy-Junutula-Cellerent-Therapeutics

Rakesh Dixit
CEO & Founder
BioNavigen

Jagath Reddy
Junutula
Sr Vice President
ModMab Therapeutics