Conference Day Two
Thursday, December 12, 2024
9:15 am Chair’s Opening Remarks
Constructing a Methodology of Target Selection to Ensure Efficiency of Strategy Whilst Prioritzing Innovation
9:30 am Panel Discussion: Curating a Target Selection Strategy With Adequate Risk Management to Maintain Investor Buy-In & Strategic Differentiation
Synopsis
- Strategizing how to penetrate the dense ADC field whilst taking adequate risks in relation to target selection or ADC design
- Understanding the degree of risk deemed acceptable by prospective investors to decide the target of choice
- Considering scenarios appropriate to advance a novel ADC with a novel task, in a high risk approach
10:15 am Concluding the Decision-Making Process When Opting for Established or Novel Targets in Alignment With Your ADC in Question
Synopsis
- Proposing how you can leave your mark on the ADC space when utilizing traditional targets as opposed to a novel target approach
- Concluding the current motivations across the ADC field: To be first-in-class or best-in-class
- Brainstorming the lessons to be learned from traditional targets which can be applied to a novel target selection strategy
10:45 am Supercharging Mass Spectrometry Techniques to Identify ADC Targets Across Tumor & Healthy Cell Populations
Synopsis
- Leveraging multiple key elements to indicate target selection, including prevalence, individual patient marker abundance, and target copy number
- Maximizing the chance of successful identification via thorough novel target validation steps to fully grasp the data collected
- Generating in-depth data to analyze the future clinical efficacy and toxicity risk to be expected with a prospective target
11:15 am Morning Refreshments & Networking
Questioning the Importance of Payload & ADC Design on Target Dynamics to Optimize Selection
11:45 am Honing the Complex Relationship of the Payload–Linker–Target Triad to Ensure Alignment Between ADC Design & Target Selection
Synopsis
- Triaging the role of the linker payload in target interaction to ensure peak ADC delivery and response
- Highlighting the biological interaction between linker, payload and target antigen to direct the strategy and decision making
- Prioritizing the stability of payload-linker binding in specific tumor environments to ensure functionality at the ADC target
12:15 pm Diagnosing the Risk of ADC Resistance Over Time, Focusing the Evolution of the Target in Response to Specific Payloads
Synopsis
- Exploring the possibility of ADC target sub-clones expressing at the target cell in a response to specific ADC therapeutics
- Diving into whether specific ADC designs lend themselves to target resistance which should be considered when deciding dosing schedules
- Confirming whether resistance risk is a property which can be quantified in the target selection process
12:45 pm Roundtable Discussion: Highlighting the Importance of Target Antigen Biology as a Key Driver of ADC Success
Synopsis
- Focusing the antigen as a functional target vs. payload delivery route to establish an allencompassing target selection strategy
- Questioning whether antigen density (sites per cell) is an important parameter? Is rapid internalization essential?
- How to select the best epitope / domain for ADC binding? Should immune effector potential (ADCC, ADCP) be strongly considered?
1:30 pm Lunch & Networking
Highlighting the Unique Challenges Faced When Identifying Bispecific Targets to Inform the Rationale Behind a Bispecific ADC Approach
2:30 pm Development of a Novel, Integrative Bioinformatics Approach for Bispecific Target Selection & Validation
Synopsis
- Integrating expression profiles with antigen biology for improved target selection
- Exploring preclinical efficacy data with novel bispecific agents with implications for disease positioning
- Discussing the importance of bispecific selectivity for improved therapeutic index and addressing the challenges of demonstrating this in preclinical models
3:00 pm Panel Discussion: A Technical Deep Dive Into Antigen Selection for Bi-Specific ADCs
Synopsis
- Outlining the criteria that is used to identify the best antigen pairs and the dynamic between the two chosen targets
- Honing the binding affinities of each antigen and how these can be tuned accordingly for a specific ADC design
- Brainstorming the target biology considerations to determine the format of the bispecific targets (e.g. 1:1 vs. 2:1)
3:45 pm Roundtable Discussion: The ADC Target White Space – What Does the Future Hold?
Synopsis
Unite as a community in an ultimate opportunity to celebrate the lessons learned over the past 3 days and discuss:
- What are the key takeaways from the presentations and discussions at the summit?
- How do we work more collaboratively as a community to drive progress?
- Where should we be this time next year to classify it as successful?