Mark Wappett

Company: Almac Discovery

Job title: Director - Bioinformatics

Seminars:

Development of a Novel, Integrative Bioinformatics Approach for Bispecific Target Selection & Validation 2:30 pm

Integrating expression profiles with antigen biology for improved target selection Exploring preclinical efficacy data with novel bispecific agents with implications for disease positioning Discussing the importance of bispecific selectivity for improved therapeutic index and addressing the challenges of demonstrating this in preclinical modelsRead more

day: Conference Day Two

Panel Discussion: A Technical Deep Dive Into Antigen Selection for Bi-Specific ADCs 3:00 pm

Outlining the criteria that is used to identify the best antigen pairs and the dynamic between the two chosen targets Honing the binding affinities of each antigen and how these can be tuned accordingly for a specific ADC design Brainstorming the target biology considerations to determine the format of the bispecific targets (e.g. 1:1 vs.…Read more

day: Conference Day Two