Bill Mallet

Company: Bolt Biotherapeutics

Job title: Senior Director, Target Validation

Seminars:

Roundtable Discussion: Highlighting the Importance of Target Antigen Biology as a Key Driver of ADC Success 12:45 pm

Focusing the antigen as a functional target vs. payload delivery route to establish an allencompassing target selection strategy Questioning whether antigen density (sites per cell) is an important parameter? Is rapid internalization essential? How to select the best epitope / domain for ADC binding? Should immune effector potential (ADCC, ADCP) be strongly considered?Read more

day: Conference Day Two

Panel Discussion: A Technical Deep Dive Into Antigen Selection for Bi-Specific ADCs 3:00 pm

Outlining the criteria that is used to identify the best antigen pairs and the dynamic between the two chosen targets Honing the binding affinities of each antigen and how these can be tuned accordingly for a specific ADC design Brainstorming the target biology considerations to determine the format of the bispecific targets (e.g. 1:1 vs.…Read more

day: Conference Day Two