Navigating the Pre-Clinical Toxicity Risk With Novel ADC Targets Through Establishing Pre-Clinical Models With High Translatability
Time: 4:00 pm
day: Conference Day One
Details:
- Curating a pre-clinical model capable of intracellular targeting, as well as, modeling the drug sensitivity of the ADC target
- Mirroring the complexity of the tumor microenvironment to gain a comprehensive understanding of the biological interactions between payload and target
- Modeling the disease progression over time to understand the target re-expression or degradation to inform dosing patterns prior to clinical advancement